Microfluidic-SERS devices for one shot limit-of-detection

作者：Kim Donghyuk; Campos Antonio R; Datt Ashish; Gao Zhe; Rycenga Matthew; Burrows Nathan D; Greeneltch Nathan G; Mirkin Chad A; Murphy Catherine J; Van Duyne Richard P; Haynes Christy L^*

来源：Analyst, 2014, 139(13): 3227-3234.

DOI：10.1039/c4an00357h

Microfluidic sensing platforms facilitate parallel, low sample volume detection using various optical signal transduction mechanisms. Herein, we introduce a simple mixing microfluidic device, enabling serial dilution of introduced analyte solution that terminates in five discrete sensing elements. We demonstrate the utility of this device with on-chip fluorescence and surface-enhanced Raman scattering (SERS) detection of analytes, and we demonstrate device use both when combined with a traditional inflexible SERS substrate and with SERS-active nanoparticles that are directly incorporated into microfluidic channels to create a flexible SERS platform. The results indicate, with varying sensitivities, that either flexible or inflexible devices can be easily used to create a calibration curve and perform a limit of detection study with a single experiment.

• 出版日期2014
• 单位西北大学