AMYLOID BETA 1-42 MONOMERS BUT NOT HIGH OLIGOMERS INDUCE AN INHIBITION OF ELECTRICAL ACTIVITY OF CULTURED NEURONAL NETWORK

作者：Kirazov Ludmil^*; Kirazov Evgeni; Gramowski Alexandra; Juegelt Konstantin; Schroeder Olaf; Naydenov Cyrill; Vassileva Evgenia; Weiss Dieter G

来源：Comptes Rendus de l Academie Bulgare des Sciences, 2010, 63(7): 1023-1028.

• amyloid beta 1-42
• aggregation forms
• electrical activity of neurons
• MEA

Amyloid beta (A beta) peptide deposits are one of the hallmarks of Alzheimer's disease (AD). For a long time it was believed that amyloid deposits in the senile plaques in the brain of patients with AD play a central role in the etiology of AD. Later many reports ascribed this role to different aggregates of A beta (from fibrils, through high oligomers to soluble A beta oligomers) through influencing different functions of brain cells, but the results are very controversial. To study the role of A beta 1-42 as monomer and in high oligomer states we used the model of neuronal networks cultured on microelectrode arrays (MEAs) where the effect of A beta 1-42 on the electrical activity can be measured. The electrical activity of the neurons was inhibited by A beta 1-42 monomers but not by A beta 1-42 high oligomers.
The presented data support the hypothesis that it is the monomeric form of A beta which participates in the pathogenesis of AD.

• 出版日期2010