Association of Genetic Polymorphisms in the LncRNAs with Gastric Cancer Risk in a Chinese Population

作者：He, Bang-Shun; Sun, Hui-Ling; Xu, Tao; Pan, Yu-Qin; Lin, Kang; Gao, Tian-Yi; Zhang, Zhen-Yu; Wang, Shu-Kui^*

来源：Journal of Cancer, 2017, 8(4): 531-536.

DOI：10.7150/jca.17519

• Gastric cancer
• polymorphism
• lncRNA

Background: Genome-wide association studies have identified that polymorphisms in 8q24 confer susceptibility to gastric cancer. Polymorphisms in the lncRNA PRNCR1, PCAT1, and CCAT2 transcribed from the 8q24 locus have a potential risk for gastric cancer.
Methods: To evaluate whether there is such an association in Chinese population, a case-control study enrolled 494 patients and 494 healthy controls was carried out. Sequenom MassARRAY platform was used for genotyping.
Results: This study showed that rs16901946 G allele was associated with increased risk of gastric cancer (AG: adjusted OR = 1.33, 95% CI = 1.02-1.73, p= 0.033; GG: adjusted OR = 2.07; 95% CI = 1.11-3.86, p= 0.023, AG/GG: adjusted OR = 1.39, 95% CI = 1.08-1.1.79, p= 0.011; additive model: adjusted OR = 1.37; 95% CI = 1.10-1.70, p= 0.004). Stratified analysis revealed that the increased risk was more evident in the cohort of younger subjects (adjusted OR = 1.84, 95% CI = 1.18-2.87, p= 0.007), males (adjusted OR = 1.55, 95% CI = 1.15-2.08, p= 0.004), positive Helicobacter pylori infection (adjusted OR = 1.44, 95% CI = 1.02-2.03, p= 0.041), gastric cardia adenocarcinoma (adjusted OR = 1.61, 95% CI = 1.10-2.35, p= 0.014), and tumor stage T1-T2 (adjusted OR = 1.58, 95% CI = 1.10-2.28, p= 0.013).
Conclusions: Our study suggested that rs16901946 G allele carriers have an increased risk of gastric cancer, and the risk could be enhanced by the interactions between the polymorphism and age, sex, Helicobacter pylori infection.

• 出版日期2017
• 单位南京医科大学