A facile and convenient one-pot synthesis of polysubstituted thiophenes from 1,3-dicarbonyl compounds in water

作者：Wang, Yan; Dong, Dewen^*; Yang, Yang; Huang, Jie; Yan, Ouyang; Liu, Qun

来源：Tetrahedron, 2007, 63(12): 2724-2728.

DOI：10.1016/j.tet.2006.12.090

• 1,3-dicarbonyl compound
• cyclization
• alpha-oxo ketene-(S,S)-acetals
• tetrabutyl ammonium bromide
• thiophenes
• water

A facile and convenient one-pot synthesis of polysubstituted thiophenes 2 and polysubstituted thieno[2,3-b]thiophenes 3 from 1, 3-dicarbonyl compounds 1 has been achieved in high yields catalyzed by tetrabutyl ammonium bromide (TBAB) in the presence of K2CO3 in water. TBAB in the aqueous phase can be recycled after the separation of organic products.

• 出版日期2007-3-19
• 单位东北师范大学