Understanding the role of probiotics and prebiotics in preventing allergic disease: evidence and methodological issues

作者：Szajewska Hania^*

来源：Immunotherapy, 2013, 5(8): 869-878.

DOI：10.2217/IMT.13.85

• allergy
• atopy
• child
• infant
• meta-analysis
• microbiota
• nutrition
• prebiotics
• prevention
• probiotics
• randomized control trial
• synbiotics

Research in the area of prevention of allergic disorders through modification of the intestinal microbiota by provision of probiotics and/or prebiotics is relatively new. This paper briefly summarizes evidence regarding the role of probiotics and/or prebiotics in reducing the risk of allergy. There are studies that show a protective effect, no effect or even a predisposing effect of using probiotics and/or prebiotics in preventing allergic disease. A variety of methodological issues are likely to contribute to current uncertainty. These include differences in the study population (high-risk vs unselected population), optimal strain selection (all probiotics are not equal), differences in definitions of outcomes, timing and duration of the interventions, and a lack of repeat studies.

• 出版日期2013-8