A "New Twist" on RGS Protein Selectivity

作者:Heximer Scott P*
来源:Structure, 2013, 21(3): 319-320.
DOI:10.1016/j.str.2013.02.011

摘要

G protein-coupled receptors mediate a wide array of physiologic stimuli and, together with their regulators such as RGS2, are essential components of cellular signaling and function. RGS2 is a selective inhibitor of the G alpha q class of alpha subunits. In this issue of Structure, Nance and colleagues provide structural insight into the features of RGS2 that mediate its potent and selective regulation of G alpha q function.

  • 出版日期2013-3-5