New insights into the burden and costs of multiple sclerosis in Europe: Results for the United Kingdom

作者：Thompson Alan; Kobelt Gisela^*; Berg Jenny; Capsa Daniela; Eriksson Jennifer; Miller David

来源：Multiple Sclerosis, 2017, 23(2_suppl): 204-216.

DOI：10.1177/1352458517708687

• Multiple sclerosis
• burden of illness
• fatigue
• cognition
• costs
• HRQoL
• United Kingdom

Introduction: In order to estimate the value of interventions in multiple sclerosis (MS) -where lifetime costs and outcomes cannot be observed -outcome data have to be combined with costs. This requires that cost data be regularly updated.
Objectives and methods: This study is part of a cross-sectional retrospective study in 16 countries collecting data on resource consumption and work capacity, health-related quality of life (HRQoL) and prevalent symptoms for patients with MS. Descriptive analyses are presented by level of disability, from the societal perspective, in EUR (2015).
Results: A total of 779 patients (mean age = 57 years) participated; 72% were below retirement age and of these, 36% were employed. Employment was related to disease severity, and MS affected productivity at work for 84% of patients. Overall, 96% and 72% of the patients experienced fatigue and cognition as a problem. Mean utility and annual costs were 0.735 and 11,400GBP at Expanded Disability Status Scale (EDSS) = 0-3, 0.534 and 22,700GBP at EDSS = 4-6.5, and 0.135 and 36,500GBP at EDSS = 7-9. The mean cost of a relapse was estimated at 790GBP.
Conclusion: This study illustrates the burden of MS on UK patients and provides current data on MS that are important for development of health policies.

• 出版日期2017-8