Different compartments of apical CA1 dendrites have different plasticity thresholds for expressing synaptic tagging and capture

作者：Sajikumar Sreedharan; Korte Martin^*

来源：Learning & Memory, 2011, 18(5): 327-331.

DOI：10.1101/lm.2095811

The consolidation process from short- to long-term memory depends on the type of stimulation received from a specific neuronal network and on the cooperativity and associativity between different synaptic inputs converging onto a specific neuron. We show here that the plasticity thresholds for inducing LTP are different in proximal and distal compartments of apical dendrites. In addition, we show interactions between the proximal and distal compartments of the apical dendrites by providing evidence that even a subthreshold stimulus can activate plasticity-related proteins, such as PKM zeta, enabling associativity between two distinct dendritic compartments in apical dendrites to occur.

• 出版日期2011-5