A Dosimetric Analysis of Intensity-modulated Radiation Therapy with Bone Marrow Sparing for Cervical Cancer

作者：Murakami Naoya^*; Okamoto Hiroyuki; Kasamatsu Takahiro; Kobayashi Kazuma; Harada Ken; Kitaguchi Mayuka; Sekii Shuhei; Takahashi Kana; Yoshio Kotaro; Inaba Koji; Morota Madoka; Sumi Minako; Toita Takafumi; Ito Yoshinori; Itami Jun

来源：Anticancer Research, 2014, 34(9): 5091-5098.

• Cervical cancer
• radical hysterectomy
• postoperative radiation therapy
• IMRT
• bone marrow sparing

Background/Aim: The purpose of the present study was to compare intensity-modulated radiation therapy (IMRT) plan with (Bone Marrow Sparing (BMS) - IMRT) or without (normal-IMRT) an intention of avoiding bone marrow in order to minimize treatment-related toxicity. Patients and Methods: Computed tomography (CT) images of 10 consecutive postoperative cervical cancer patients were used. All patients were already treated by normal-IMRT. BMS-IMRTs were created for this study and dose-volume histogram parameters were compared. Results: Both planning target volume (PTV) D95% and D97% were statistically lower in BMS-IMRT than normal-IMRT, however, the difference was lower than 3%. There were no statistical differences between BMS-IMRT and normal-IMRT in the mean value of rectum V-30Gy, V-50Gy; bladder V-45Gy, V-50Gy; Bowel V-35Gy, and V-50Gy. Both in whole pelvic bone (WPB) and inner cavity of pelvic bone (ICPB), the mean value of V-10Gy, V-30Gy, and V-40Gy of BMS-IMRT were statistically lower than that of normal-IMRT. Conclusion: Both lower and higher dose for WPB as well as ICPB were effectively lowered by BMS-IMRT.

• 出版日期2014-9