Post-transcriptional regulation of the Ras-ERK/MAPK signaling pathway

作者：Whelan Jarrett T; Hollis Sarah E; Cha Dong Seok; Asch Adam S; Lee Myon Hee^*

来源：Journal of Cellular Physiology, 2012, 227(3): 1235-1241.

DOI：10.1002/jcp.22899

The Ras-ERK/MAP (Mitogen-Activated Protein) kinase signaling pathway governs many cellular processes such as proliferation, differentiation, cell fate, homeostasis, and survival in all eukaryotes. Constitutive activation of the Ras-ERK/MAPK signaling pathway often leads to promotion of abnormal cell growth and tumorigenesis. Although the regulation of the Ras-ERK/MAPK signaling pathway by post-translational modification has been well elucidated, post-transcriptional regulations of this pathway are beginning to emerge in invertebrates and this work is extended to humans. In this review, we describe the conserved regulation of Ras-ERK/MAPK signaling by RNA-binding proteins (PUF, KH-domain, HuR, and LARP) and microRNAs (let-7 family miRNAs) and important implications for human diseases including cancers. J. Cell. Physiol. 227: 12351241, 2012.

• 出版日期2012-3