An internally quenched peptide as a new model substrate for rhomboid intramembrane proteases.

作者：Arutyunova Elena; Jiang Zhenze; Yang Jian; Kulepa Ayodeji N; Young Howard S; Verhelst Steven; O'Donoghue Anthony J; Lemieux M Joanne

来源：Biological Chemistry, 2018, 0(0): 1389-1397.

DOI：10.1515/hsz-2018-0255

• FRET
• GlpG
• Bicelles
• Intramembrane protease
• Kinetics
• Membrane protein
• Peptide
• Rhomboid protease
• Serine protease

Rhomboids are ubiquitous intramembrane serine proteases that cleave transmembrane substrates. Their functions include growth factor signalling, mitochondrial homeostasis, and parasite invasion. A recent study revealed that the E. coli rhomboid protease EcGlpG is essential for its extraintestinal pat...

• 出版日期2018