Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization

作者：Formentini Laura; Santacatterina Fulvio; Nunez de Arenas Cristina; Stamatakis Konstantinos; Looez Martinez David; Logan Angela; Fresno Manuel; Smits Ron; Murphy Michael P; Cuezva Jose M^*

来源：Cell Reports, 2017, 19(6): 1202-1213.

DOI：10.1016/j.celrep.2017.04.036

Mitochondria are signaling hubs in cellular physiology that play a role in inflammatory diseases. We found that partial inhibition of the mitochondrial ATP synthase in the intestine of transgenic mice triggers an anti-inflammatory response through NF kappa B activation mediated by mitochondrial mtROS. This shielding phenotype is revealed when mice are challenged by DSS-induced colitis, which, in control animals, triggers inflammation, recruitment of M1 pro-inflammatory macrophages, and the activation of the pro-oncogenic STAT3 and Akt/mTOR pathways. In contrast, transgenic mice can polarize macrophages to the M2 anti-inflammatory phenotype. Using the mitochondria-targeted antioxidant MitoQ to quench mtROS in vivo, we observe decreased NF kappa B activation, preventing its cellular protective effects. These findings stress the relevance of mitochondrial signaling to the innate immune system and emphasize the potential role of the ATP synthase as a therapeutic target in inflammatory and other related diseases.

• 出版日期2017-5-9