Administration of antiretroviral medication via enteral tubes

作者：Prohaska Emily S^*; King Allison R

来源：American Journal of Health-System Pharmacy, 2012, 69(24): 2140-2146.

DOI：10.2146/ajhp120106

Purpose. Case reports and other published or manufacturer-provided data on the administration of antiretroviral agents through enteral feeding tubes are reviewed. %26lt;br%26gt;Summary. There is very limited published evidence to guide clinicians in the delivery of therapies for human immunodeficiency virus (HIV) infection by feeding tubes, especially crushed tablets and capsule contents. A search of the primary literature (through February 2012) identified a total of nine articles describing the delivery of highly active antiretroviral therapy (HAART) agents via gastrostomy (G), jejunostomy, and other feeding tubes; correspondence with pharmaceutical manufacturers yielded additional information. Most of the published evidence (from two prospective studies, one retrospective study, and six case reports) pertains to the treatment of HIV-infected children (33 of 40 cases). Although not a primary endpoint of any of the reviewed studies, viral suppression was documented in 29 of the 40 patients referenced in the reviewed articles. Manufacturer-provided information indicates that crushed darunavir tablets in suspension, as well as oral solutions of ritonavir and lopinavir ritonavir, can be administered through G-tubes without significant loss of therapeutic efficacy. %26lt;br%26gt;Conclusion. Data regarding enteral feeding tube administration are available for 63% of commercially available oral HAART agents and are primarily limited to case reports specific to the pediatric population. Am J Health-Syst Pharm. 2012; 69:2140-6

• 出版日期2012-12-15