Asymmetric Synthesis of alpha-Alkylidene-beta-hydroxy-gamma-butyrolactones via Enantioselective Tandem Michael-Aldol Reaction

作者:Lee Sung Il; Jang Jin Hee; Hwang Geum Sook*; Ryu Do Hyun
来源:Journal of Organic Chemistry, 2013, 78(2): 770-775.
DOI:10.1021/jo302369q

摘要

A simple and efficient method for the asymmetric synthesis of alpha-alkylidene-beta-hydroxy-gamma-butyrolactones and related natural products was developed on the basis of the catalytic asymmetric tandem Michael-aldol reaction and simple transformations. The synthetic utility of this method was illustrated by the facile synthesis of trisubstituted gamma-butyrolactone natural products.

  • 出版日期2013-1-18