Celiac Disease Screening among Healthy Blood Donors in Hungary

作者：Sardy M^*; Kornsee Z; Kelemen D; Papp S; Medvecz M; Karpati S

来源：Zeitschrift für Gastroenterologie, 2013, 51(11): 1234-1238.

DOI：10.1055/s-0033-1335450

• tissue transglutaminase
• endomysial antibodies
• prevalence
• celiac disease
• sprue

Background: Celiac disease (CD) is a common chronic systemic autoimmune disease in Europe. The prevalence of CD in Hungarian children is estimated at 1.2-1.4%. To date, however, no data on adult CD prevalence has been published. %26lt;br%26gt;Aims: Analysis of the serological evidence for CD among Hungarian adults in order to estimate its prevalence. %26lt;br%26gt;Methods: Plasma samples from 4155 healthy blood donors were anonymously screened for circulating IgA autoantibodies by a highly sensitive tissue transglutaminase ELISA. Positive results were subsequently confirmed by endomysial antibody test. %26lt;br%26gt;Results: Endomysial antibody test confirmed positivity in 25 samples suggesting a prevalence of CD of at least 0.6% (1:166). Since no identification on the samples was provided, no further examinations could be done on endomysial antibody positive individuals. %26lt;br%26gt;Conclusions: The first serological screening study among healthy Hungarian adult blood donors showed a prevalence of CD similar to other central European countries and lower than that in Hungarian children. Among countries worldwide, the Hungarian prevalence of CD appears to be in the mid-range, although pediatric data suggest a higher prevalence.

• 出版日期2013-11