Age and androgen-deprivation therapy on exercise outcomes in men with prostate cancer

作者：Alberga Angela S; Segal Roanne J; Reid Robert D; Scott Chris G; Sigal Ronald J; Khandwala Farah; Jaffey James; Wells George A; Kenny Glen P^*

来源：Supportive Care in Cancer, 2012, 20(5): 971-981.

DOI：10.1007/s00520-011-1169-x

• Aerobic exercise training
• Resistance exercise training
• Cardiorespiratory fitness
• Muscular strength
• Body composition

Purpose The purpose of this study is to examine the effects of age (%26lt;= 65 years or %26gt;65 years) and androgen-deprivation therapy (ADT, presence or absence) as factors that may predict changes in body composition and fitness following a 24-week exercise program in prostate cancer patients. %26lt;br%26gt;Methods One hundred twenty-one men were randomly allocated to either: (1) aerobic exercise (AE), (2) resistance exercise (RE), or (3) usual care (UC). Body composition was assessed by DXA. Aerobic fitness was assessed through a maximal treadmill test. Muscular strength was assessed by leg extension and bench press using the eight-repetition maximum test. Responses were compared between younger (%26lt;= 65 years) and older (%26gt;65 years) patients with or without ADT. %26lt;br%26gt;Results There did not appear to be an interaction between age and ADT on body composition or fitness, nor were there any significant changes in body composition for participants %26lt;= 65 years. In participants aged %26gt;65 years, lean mass decreased in AE (p=0.013) and UC (p=0.006), but was preserved in RE. In participants receiving ADT, there was a decrease in lean mass in AE (p=0.003) and UC (p%26lt;0.001) but not in RE. The non-ADT group did not show any changes in body composition but did show improvements in muscular fitness following resistance training (p%26lt;0.001). %26lt;br%26gt;Conclusion Changes in body composition and physical fitness following a 24-week exercise program in men with prostate cancer are not influenced by age and/or ADT. Resistance training appears to attenuate the age-related decrease in lean mass and increase in body fat in older patients with prostate cancer and those receiving ADT.

• 出版日期2012-5