U1 snRNA Rewrites the "Script"

作者：Merkhofer Evan C; Johnson Tracy L^*

来源：Cell, 2012, 150(1): 9-11.

DOI：10.1016/j.cell.2012.06.017

Expression of eukaryotic mRNAs requires the collaboration of a host of RNA processing factors acting upon the transcript. Berg et al. describe how a pre-mRNA splicing factor modulates the activity of the polyadenylation machinery to regulate mRNA length, with important implications for isoform expression in activated neuronal and immune cells.

• 出版日期2012-7-6