Adverse drug events in cognitively impaired elderly patients

作者：Ganjavi Hooman; Herrmann Nathan; Rochon Paula A; Sharma Papita; Lee Monica; Cassel Daniel; Freedman Morris; Black Sandra E; Lanctot Krista L^*

来源：Dementia and Geriatric Cognitive Disorders, 2007, 23(6): 395-400.

DOI：10.1159/000101454

• adverse drug events
• cognitive impairment
• natural health products
• elderly population

Background/Aims: Adverse drug events (ADEs) are a frequent problem encountered in the elderly. The aim of this study was to elucidate the factors that influence ADEs in an elderly population with cognitive impairment. Methods: 242 patients were recruited from dementia clinics and assessed after 6 months for ADEs. The use of natural health products (NHPs) was also documented. Results: Backward logistic regression found that higher age ( OR = 1.06; 95% CI 1.01 - 1.12), and greater cognitive impairment ( OR = 0.94; 95% CI 0.90 - 0.98) were associated with an increased risk of developing an ADE while the use of NHPs ( OR = 0.32; 95% CI 0.13 - 0.79) was associated with a decreased risk (chi(2) = 27.6, p < 0.001). Conclusion: Risk of ADEs increased with greater age and cognitive impairment but decreased with the use of NHPs.

• 出版日期2007