Lack of association between the 389C > T polymorphism (rs769217) in the catalase (CAT) gene and the risk of vitiligo: An update by meta-analysis

作者：He Jie; Li Xiaoyan; Li Yunhui; Ren Bocheng; Sun Jian; Zhang Wei; Li Wancheng^*

来源：Australasian Journal of Dermatology, 2015, 56(3): 180-185.

DOI：10.1111/ajd.12204

• catalase
• meta-analysis
• polymorphism
• risk
• vitiligo

Background/ObjectivesThe catalase (CAT) T/C at codon 389in the exon 9 polymorphism has been implicated in susceptibility to vitiligo but a large number of studies have reported inconclusive results. The purpose of this study is to evaluate the association between the catalase gene polymorphism (389C>T) and the risk of vitiligo.
MethodsA meta-analysis was carried out to analyse the association between 389C>T and vitiligo risk.
ResultsEight case-control studies with 2923 cases and 4237 controls were included in the meta-analysis. The results indicated that there was no association between this polymorphism and vitiligo (TT+CT versus CC: OR=1.08, 95% CI=0.98-1.20, P=0.11, T versus C: OR=1.07, 95% CI=0.99-1.16, P=0.092). In a subgroup analysis by ethnicity, no significant association between the CAT gene 389C>T polymorphism and vitiligo susceptibility was found in Caucasians (TT+CT versus CC: OR=1.15, 95% CI=0.98-1.35, P=0.08; T versus C: OR=1.07, 95% CI=0.97-1.19, P=0.173) and Asians (TT+CT versus CC: OR=1.12, 95% CI =0.93-1.34, P=0.23; T versus C: OR=1.07, 95% CI=0.94-1.21, P=0.321).
ConclusionsOur results suggest that 389C>T may not contribute to vitiligo susceptibility. However, larger primary studies with the consideration of gene-environment and gene-gene interactions are still required to further evaluate the interaction of CAT gene polymorphism with vitiligo susceptibility.

• 出版日期2015-8
• 单位成都医学院