A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

作者：Smith Catherine J^*; Nikbin Nikzad; Ley Steven V; Lange Heiko; Baxendale Ian R

来源：Organic and Biomolecular Chemistry, 2011, 9(6): 1938-1947.

DOI：10.1039/c0ob00815j

Having demonstrated in the preceding publication the flow synthesis of aryl azides, we describe here a general protocol for the in-line purification of these versatile intermediates. As part of this investigation, we evaluated the use of ReactIR 45m as a tool for real-time detection of hazardous azide contaminants. This azide synthesis and purification process was then incorporated into a multistep flow sequence to generate a small collection of 5-amino-4-cyano-1,2,3-triazoles directly from aniline starting materials in a fully automated fashion.

• 出版日期2011