A Molecular Diagnostic Test for Persistent Mullerian Duct Syndrome in Miniature Schnauzer Dogs

作者：Pujar S; Meyers Wallen V N^*

来源：Sexual Development, 2010, 3(6): 326-328.

DOI：10.1159/000273264

• DNA test
• Dog
• Miniature schnauzer
• Persistent Mullerian duct syndrome

In persistent Mullerian duct syndrome (PMDS), Mullerian ducts fail to regress in males during sexual differentiation. In the canine miniature schnauzer model, PMDS is caused by a C to T transition in exon 3 of the Mullerian inhibiting substance type II receptor (MISRII), which introduces a DdeI restriction site. Here we report a molecular diagnostic test for PMDS in the miniature schnauzer to identify affected dogs and carriers. As our test results suggest that the mutation is identical by descent in affected dogs of this breed, the test could be used to eliminate this mutation from the miniature schnauzer breed worldwide.

• 出版日期2010