Novel 1,2,4-Triazolo[1,5-a]pyridines and Their Fused Ring Systems Attenuate Oxidative Stress and Prolong Lifespan of Caenorhabiditis elegans

作者：Mekheimer Ramadan Ahmed^*; Sayed Ahmed Amir Radwan; Ahmed Eltaib Ali

来源：Journal of Medicinal Chemistry, 2012, 55(9): 4169-4177.

DOI：10.1021/jm2014315

In this paper we report the synthesis of some novel 1,2,4-triazolo [1,5-a]pyridine and azolotriazolopyridine ring systems. The products were screened for various types of activity like antibacterial, antifungal, and antioxidative activity. Compound 13 was found to pose an antioxidative activity. In addition, this compound was found to extend the life span of Caenorhabiditis elegans under standard laboratory conditions and reduces both heat and chemical induced oxidative stress in C. elegans in a dose-dependent manner. Furthermore, treatment of worms with compound 13 was found to significantly attenuate the formation of advanced glycation end products and malondialdehyde in a dose-dependent manner.

• 出版日期2012-5-10