Hydrocortisone release from tablets based on bioresorbable poly(ether-ester-urethane)s

作者：Manuel Orozco Castellanos Luis; Marcos Fernandez Angel; Josabad Alonso Castro Angel; Gonzalez Garcia Gerardo; Eduardo Baez Garcia Jose; Cesar Rivera Leyva Julio; Ramon Zapata Morales Juan; Joel Ruiz Padilla Alan

来源：Brazilian Journal of Pharmaceutical Sciences, 2017, 53(1): UNSP e16144.

DOI：10.1590/s2175-97902017000116144

• Bioresorbable polyurethanes
• Drug delivery
• Hydrocortisone
• Macrodiol

Bioresorbable linear poly(ether-ester-urethane)s with different hydrophilic characteristics were synthesized from triblock copolymers of poly(epsilon-caprolactone)-poly(ethylene oxide)-poly(epsilon-caprolactone) (PCL-PEO) as macrodiols, and L-lysine diisocyanate (LDI) or hexamethy lenediisocyanate (HDI) were used as the required diisocyanates. Macrodiols were obtained by ring-opening polymerization (ROP) of epsilon-caprolactone (CL). Polyurethanes were synthesized by the reaction of the triblock copolymers with LDI or HDI in solution using stannous 2-ethylhexanoate as catalyst. Polyurethane tablets were fabricated and investigated as prospective drug delivery systems. The effect of the PEO content on the polymers' performance as drug carriers was evaluated. It was found that water provoked more swelling and erosion of polymers with higher contents of PEO. The hydrocortisone release profiles were analyzed using the Ritger-Peppas approximation. An anomalous release behaviour (values of n higher than 0.5) was found for most of the analyzed samples.

• 出版日期2017