Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss

作者：Bellantuono Ilaria^*; Aldahmash Abdullah; Kassem Moustapha

来源：Biochimica et Biophysica Acta-Molecular Basis of Disease, 2009, 1792(4): 364-370.

DOI：10.1016/j.bbadis.2009.01.008

• Mesenchymal stem cell
• Ageing
• Marrow stromal cell
• Senescence
• Telomeres Notch

Marrow stromal cells (MSC) are thought to be stem cells with osteogenic potential and therefore responsible for the repair and maintenance of the skeleton. Age related bone loss is one of the most prevalent diseases in the elder population. It is controversial whether MSC undergo a process of aging in vivo, leading to decreased ability to form and maintain bone homeostasis with age. In this review we summarize evidence of MSC involvement in age related bone loss and suggest new emerging targets for intervention.

• 出版日期2009-4