AlkylFluor: Deoxyfluorination of Alcohols

作者:Goldberg Nathaniel W; Shen Xiao; Li Jiakun; Ritter Tobias*
来源:Organic Letters, 2016, 18(23): 6102-6104.
DOI:10.1021/acs.orglett.6b03086

摘要

A practical, high-yielding method for the deoxy-fluorination of alcohols is presented using AlkylFluor, a novel salt analogue of PhenoFluor. AlkylFluor is readily prepared on multigram scale and is stable to long-term storage in air and exposure to water. The practicality and applicability of this method is demonstrated with a variety of primary and secondary alcohol substrates.

  • 出版日期2016-12-2