Association of Macrophage Inflammation Biomarkers With Progression of Subclinical Carotid Artery Atherosclerosis in HIV-Infected Women and Men

作者：Hanna David B^*; Lin Juan; Post Wendy S; Hodis Howard N; Xue Xiaonan; Anastos Kathryn; Cohen Mardge H; Gange Stephen J; Haberlen Sabina A; Heath Sonya L; Lazar Jason M; Liu Chenglong; Mack Wendy J; Ofotokun Igho; Palella Frank J; Tien Phyllis C; Witt Mallory D; Landay Alan L; Kingsley Lawrence A; Tracy Russell P; Kaplan Robert C

来源：Journal of Infectious Diseases, 2017, 215(9): 1352-1361.

DOI：10.1093/infdis/jix082

• atherosclerosis
• galectin-3
• galectin-3 binding protein
• HIV infection
• inflammation
• intima-media thickness
• macrophages
• monocytes
• soluble CD14
• soluble CD163

Background. Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation and vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection.
Methods. We examined 778 women (74% HIV+) in the Women's Interagency HIV Study and 503 men (65% HIV+) in the Multicenter AIDS Cohort Study who underwent repeated B-mode carotid artery ultrasound imaging in 2004-2013. We assessed baseline associations of the serum macrophage inflammation markers soluble (s) CD163, sCD14, galectin-3 (Gal-3), and Gal-3 binding protein (Gal-3BP) with carotid plaque formation (focal intima-media thickness >1.5 mm) over 7 years.
Results. Marker levels were higher in HIV+ persons versus HIV- persons. Presence of focal plaque increased over time: from 8% to 15% in women, and 24% to 34% in men. After adjustment for demographic, behavioral, and cardiometabolic factors, and CRP and interleukin-6, each standard deviation increase in sCD14 was associated with increased plaque formation (risk ratio [RR] 1.24, 95% confidence interval [CI] 1.07-1.43). This pattern was consistentby sex. sCD163 was associated with plaque formation in virally suppressed HIV+ men (RR 1.52, 95% CI 1.04-2.22); Gal-3BP and Gal-3 were not associated with increased plaque.
Conclusions. sCD14 and sCD163 may play important roles in atherogenesis among HIV+ persons.

• 出版日期2017-5-1