Vitamin D Supplementation, Moderate Sun Exposure, and Control of Immune Diseases

作者：Hart Prue H^*

来源：Discovery Medicine, 2012, 13(73): 397-404.

There is considerable debate about the benefits of vitamin D supplementation for multiple sclerosis, allergic asthma, and type 1 diabetes. This has been driven mainly by observational studies linking vitamin D deficiency and insufficiency with increased prevalence of autoimmune and other diseases driven by immune processes. Randomized controlled trials of vitamin D supplementation to treat these (and other) diseases have been disappointing. This review examines the evidence that circulating vitamin D levels provide a surrogate measure of sun exposure and that it is the other molecules and pathways induced by sun exposure, rather than vitamin D-driven processes, that explain many of the benefits often attributed to vitamin D. [Discovery Medicine 13(73):397-404, June 2012]

• 出版日期2012-6