A Versatile Synthesis of Annulated Carbazole Analogs Involving a Domino Reaction of Bromomethylindoles with Arenes/Heteroarenes

作者：Dhayalan Vasudevan; Clement J Arul; Jagan Radhakrishnan; Mohanakrishnan Arasambattu K^*

来源：European Journal of Organic Chemistry, 2009, 2009(4): 531-546.

DOI：10.1002/ejoc.200801018

• Alkaloids
• Sigmatropic rearrangement
• Cyclization
• Annulation
• Arenes

A ZnBr(2)-mediated arylation of aryl/heteroaryl methyl bromides with arenes at 80 degrees C led to the formation of arylated products, which underwent subsequent. 1,5-sigmatropic rearrangement followed by electrocyclization and aromatization with loss of a diethylmalonate unit to afford the corresponding annulated products.

• 出版日期2009-2