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摘要
The tumour suppressor PTEN (phosphatase and tensin deleted on chromosome 10) is an important regulator of cell proliferation and migration. In this issue of The EMBO Journal, Lima-Fernandes and colleagues show that the universal signalling scaffold protein, beta-arrestin dynamically interacts with PTEN, through a phosphorylation-controlled switch. This protein-protein interaction profoundly influences the ability of PTEN to regulate both cell proliferation, through activation of its lipid phosphatase activity, and enhance cell migration by unblocking the inhibitory effect of the PTEN C2 domain and by recruiting activated ROCK into a beta-arrestin/PTEN 'signalosome'.
- 出版日期2011-7-6
