A new enniatin antibiotic from the endophyte Fusarium tricinctum Corda

作者：Zaher Ahmed M; Makboul Makboul A; Moharram Ahmad M; Tekwani Babu L; Calderon Angela I^*

来源：Journal of Antibiotics, 2015, 68(3): 197-200.

DOI：10.1038/ja.2014.129

Enniatins (ENs), a group of antibiotics commonly produced by various strains of Fusarium, are six-membered cyclic depsipeptides formed by the union of three molecules of D-alpha-hydroxyisovaleric acid and three N-methyl-L-amino acids. The endophyte Fusarium tricinctum Corda was isolated from the fruits of Hordeum sativum Jess. and cultivated on a rice medium. The fungal metabolites were extracted with methanol and were identified, employing liquid chromatography-mass spectrometry as ENs A, A1, B, B1, B2 and Q. EN Q is a new analog of EN A and the occurrence of EN B2 is reported for the first time from this endophyte, in addition to four well-known ENs (A, A1, B and B1). The methanol extract of F. tricinctum showed mild antibacterial and antileishmanial activities. Additionally the tested extract displayed inhibition of the activity of thioredoxin reductase enzyme of Plasmodium falciparum.

• 出版日期2015-3