Association of Cardiovascular Factors and Alzheimer's Disease Plasma Amyloid-beta Protein in Subjective Memory Complainers

作者：Bates Kristyn A; Sohrabi Hamid R; Rodrigues Mark; Beilby John; Dhaliwal Satvinder S; Taddei Kevin; Criddle Arthur; Wraith Megan; Howard Matthew; Martins Georgia; Paton Athena; Mehta Pankaj; Foster Jonathan K; Martins Ian J; Lautenschlager Nicola T; Mastaglia Frank L; Laws Simon M; Gandy Samuel E; Martins Ralph N^*

来源：Journal of Alzheimer's Disease, 2009, 17(2): 305-318.

DOI：10.3233/JAD-2009-1050

• Aging
• amyloid-beta
• apolipoprotein E
• cholesterol
• dementia
• high density lipoprotein

A strong link is indicated between cardiovascular disease (CVD) and risk for developing Alzheimer's disease (AD), which may be exacerbated by the major AD genetic risk factor apolipoprotein E epsilon 4 (APOE epsilon 4). Since subjective memory complaint (SMC) may potentially be an early indicator for cognitive decline, we examined CVD risk factors in a cohort of SMC. As amyloid-beta (A beta) is considered to play a central role in AD, we hypothesized that the CVD risk profile (increased LDL, reduced HDL, and increased body fat) would be associated with plasma A beta levels. We explored this in 198 individuals with and without SMC (average age = 63 years). Correlations between A beta(40) and HDL were observed, which were stronger in non-APOE epsilon 4 carriers (rho = -0.315, p < 0.001) and in SMC (rho = -0.322, p = 0.01). There was no relationship between percentage body fat and A beta(40) in this cohort. Age and HDL remained predictive for plasma A beta(40) using multivariate regression analysis. We report a novel negative association between HDL and A beta, which if demonstrated to be causal has implications for the development of lifestyle interventions and/or novel therapeutics. The relationship between HDL and A beta and the potential significance of such an association needs to be validated in a larger longitudinal study.

• 出版日期2009