Non-alcoholic fatty liver disease in 2016

作者：Townsend S A; Newsome Philip N

来源：British Medical Bulletin, 2016, 119(1): 143-156.

DOI：10.1093/bmb/ldw031

• non-alcoholic fatty liver disease
• cardiovascular disease
• NASH
• fibrosis
• metabolic syndrome
• obesity
• assessment
• treatment

Non-alcoholic fatty liver disease is the commonest cause of liver disease worldwide, and is rapidly becoming the leading indication for liver transplantation.
Original articles, reviews and meta-analyses, guidelines.
NAFLD strongly correlates with obesity and insulin resistance; currently, the best management strategy is weight loss and treatment of the metabolic syndrome.
Recent data suggest that the presence of fibrosis and not non-alcoholic steatohepatitis (NASH) is the predictor of clinical outcome.
Many phase 2 and 3 trials are underway. Drugs hoped to be effective are obeticholic acid, elafibranor, glucagon-like peptide-1 analogues and CCR2/5 inhibitors.
Improved understanding of the pathophysiology of NAFLD should help us identify which patients progress to significant liver disease and to develop therapies to target this population.

• 出版日期2016-9