Anti-inflammatory Activities of Ethylacetate Extract of Rehmannia glutinosa in LPS-induced RAW 264.7 Cells

作者：Jin Chang Hyun; Lee Young Man; Kang Min Ah; Park Yong Dae; Choi Dae Seong; Byun Myung Woo; Jeong Il Yun^*

来源：Food Science and Biotechnology, 2009, 18(4): 923-927.

• Rehmannia glutinosa
• nitric oxide
• inducible nitric oxide synthase
• nuclear factor-kappa B
• reactive oxygen species

This study is to investigate the anti-inflammatory effects of the ethylacetate extract of Rehmannia glutinosa (RGEAE). The anti-inflammatory activities using nitric oxide (NO), cytokine, and chemokine production in lipopolysaccharide (LPS)-induced RAW 264.7 cells were checked. Results indicated that RGEAE. Suppressed the NO, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1) production in a dose-dependent manner. Inhibition of NO formation was due to a decrease in inducible NOS (iNOS) expression. It was also found that the anti-inflammatory activities of RGEAE resulted from its inhibitory role on the nuclear factor (NF)-kappa B activation and reactive oxygen species (ROS) production. Therefore, it is suggested that RGEAE has potential as a therapeutic Material to attenuate the inflammatory disease such as rheumatoid arthritis.

• 出版日期2009-8