Aberrant Expression of Osteopontin and E-Cadherin Indicates Radiation Resistance and Poor Prognosis for Patients with Cervical Carcinoma

作者：Huang, Xinqiong; Qian, Yujie; Wu, Hainan; Xie, Xiaoxue; Zhou, Qin; Wang, Ying; Kuang, Weilu; Shen, Lin; Li, Kai; Su, Juan; Shen, Liangfang^*; Chen, Xiang

来源：Journal of Histochemistry and Cytochemistry, 2015, 63(2): 88-98.

DOI：10.1369/0022155414561329

• locally advanced cervical squamous cell carcinoma
• radiation resistance
• osteopontin
• E-cadherin
• epithelial-mesenchymal transition
• immunohistochemistry

Radiotherapy is the first-line treatment for all stages of cervical cancer, whether it is used for radical or palliative therapy. However, radioresistance of cervical cancer remains a major therapeutic problem. Consequently, we explored if E-cadherin (a marker of epithelial-mesenchymal transition) and osteopontin could predict radioresistance in patients with locally advanced cervical squamous cell carcinoma (LACSCC). Patients were retrospectively reviewed and 111 patients divided into two groups (radiation-resistant and radiation-sensitive groups) according to progression-free survival (PFS). In pretreated paraffin-embedded tissues, we evaluated E-cadherin and osteopontin expression using immunohistochemical staining. The percentage of patients with high osteopontin but low E-cadherin expression in the radiation-resistant group was significantly higher than those in the radiation-sensitive group (p<0.001). These patients also had a lower 5-year PFS rate (p<0.001). Our research suggests that high osteopontin but low E-cadherin expression can be considered as a negative, independent prognostic factor in patients with LACSCC ([Hazard ratios (95% CI) 6.766 (2.940, 15.572)], p<0.001).

• 出版日期2015-2
• 单位中南大学