Novel dihydropyridine thioglycosides and their corresponding dehydrogenated forms as potent anti-hepatocellular carcinoma agents

作者：Elgemeie Galal H^*; El Naggar Dina H

来源：Nucleosides Nucleotides & Nucleic Acids, 2018, 37(4): 199-216.

DOI：10.1080/15257770.2018.1457161

• dihydropyridinethiones
• dihydropyridine thioglycosides
• pyridinethiones
• pyridine thioglycosides
• antimetabolites

A novel method for preparation of a new class of dihydropyridine thioglycosides and their corresponding dehydrogenated forms, via reaction of piperidinium salts of dihydropyridinethiones with 2,3,4,6-tetra-O-acetyl--D-gluco- and galactopyranosyl bromides has been studied. The evaluation of antiproliferative activity against HepG-2 cell lines (liver carcinoma cell lines) of the dihydropyridine thioglycosides and pyridine thioglycosides revealed that many of the thioglycosides have interesting antitumor activities specifically 5c, 5g, 5l, 5o, 5p, 7a, 7i, 7p, 8b, 8f, 8s, and 8v.

• 出版日期2018