A synthesis of (-)-ebelactones A and B

作者：Cooksey John P; Ford Rhonan; Kocienski Philip J^*; Pelotier Beatrice; Pons Jean Marc

来源：Tetrahedron, 2010, 66(33): 6462-6467.

DOI：10.1016/j.tet.2010.05.072

• Ebelactone A
• Ebelactone B
• 1,2-Metallate rearrangement
• Hoppe homoaldol reaction
• Roush crotylmetallation

A synthesis of the beta-lactone esterase inhibitors (-)-ebelactones A and B is described. The synthesis features the use of a Hoppe homoaldol reaction and a Cu(I)-mediated 1,2-metallate rearrangement of a metallated enol carbamate as key fragment linkage reactions.

• 出版日期2010-8-14