Design, synthesis and CoMFA studies of OEA derivatives as FAAH inhibitors

作者：Han, Daxiong; Wang, Biyan; Jin, Hui; Wang, Haiyan^*; Chen, Meimei

来源：Medicinal Chemistry Research, 2017, 26(11): 2951-2966.

DOI：10.1007/s00044-017-1995-6

• OEA derivatives
• Synthesis
• FAAH inhibitors
• CoMFA analyzes

A total of 26 novel oleoylethanolamide derivatives were designed, synthesized, and characterized. All synthesized targets compounds were screened for their inhibitory activities against fatty acid amide hydrolase. Among of them, 13 compounds inhibit fatty acid amide hydrolase by 50% at the concentration of 100 mu M. Of these compounds, the most active one is compound 9, which inhibit fatty acid amide hydrolase activity 98.35% at the concentration of 100 mu M. Comparative molecular field analysis analyzes were performed based on obtained biological activities data and resulted in a statistically reliable comparative molecular field analysis model with high predictive abilities (r(2) = 0.978, q(2) = 0.613).

• 出版日期2017-11
• 单位国家海洋局第三海洋研究所; 厦门大学