Antibiotic Resistance of Helicobacter Pylori Isolated in the Southeast Coastal Region of China

作者：Su, Peng; Li, Youming; Li, Hongzhang; Zhang, Jiakun; Lin, Lang; Wang, Qunying; Guo, Feng; Ji, Zizhong; Mao, Jibo; Tang, Wuheng; Shi, Zhengchao; Shao, Wei; Mao, Junliang; Zhu, Xinjian; Zhang, Xiaofeng; Tong, Yuefeng; Tu, Huimin; Jiang, Mizu; Wang, Zhiyong; Jin, Fengzhe; Yang, Ningmin; Zhang, Jianzhong

来源：Helicobacter, 2013, 18(4): 274-279.

DOI：10.1111/hel.12046

• Helicobacter pylori
• antibiotic resistance
• clarithromycin
• metronidazole
• levofloxacin
• amoxicillin

Background The resistance of Helicobacter pylori (H.pylori) to antibiotics is increasing worldwide, lowering its efficacy in current eradication therapies. This study evaluated H.pylori resistance to antibiotics in the southeast coastal region of China and suggests appropriate alternatives. Materials and Methods Seventeen thousand seven hundred and thirty one H.pylori strains were collected from eight areas of two provinces in coastal southeast China from 2010 to 2012. The resistance of these strains to six antibiotics was tested using the agar dilution method. Results The resistance rates to clarithromycin, metronidazole, levofloxacin, amoxicillin, gentamicin and furazolidone were 21.5, 95.4, 20.6, 0.1, 0.1 and 0.1%, respectively. Double, triple and quadruple antibacterial resistant percentages were 25.5, 7.5 and 0.1%, respectively. A positive association between the resistance to levofloxacin and to clarithromycin was found, but there was a negative correlation in the resistances to levofloxacin and to metronidazole. Conclusions The prevalence of H.pylori resistance to clarithromycin, metronidazole, levofloxacin and multiple antibiotics in coastal southeast China is high. Choice of therapy should be individualized based on a susceptibility test in this region of the country.

• 出版日期2013-8
• 单位苏州大学; 杭州师范大学; 舟山医院; 浙江大学; 宿州学院; 杭州市第一人民医院; 中国疾病预防控制中心传染病预防控制所; 传染病预防控制国家重点实验室