Amyloid Imaging Using High-Field Magnetic Resonance

作者：Amatsubo Tomone; Yanagisawa Daijiro; Morikawa Shigehiro; Taguchi Hiroyasu; Tooyama Ikuo^*

来源：Magnetic Resonance in Medical Sciences, 2010, 9(3): 95-99.

• Alzheimer's disease
• amyloid imaging
• cell tracking
• contrast agents
• F-19-MRI

The formation of senile plaques followed by deposition of amyloid beta peptides (A beta) are the earliest pathological changes of Alzheimer's disease (AD); thus, detection of the plaques remains the most important early diagnostic indicator of AD. Amyloid imaging is a noninvasive technique for visualizing senile plaques in the brains of patients with Alzheimer's using positron emission tomography (PET) or magnetic resonance (MR) imaging. Several types of probes have been developed for PET, but few ligands have been developed specifically for MR imaging detection of amyloid plaques. This review presents recent advances in amyloid imaging using MR imaging and includes our studies.

• 出版日期2010