Antiplasmodial procyanidins derivatives from Chinese Hawthorn

作者：Park Yool Jin; Chung Ill Min; Moon Hyung In^*

来源：Immunopharmacology and Immunotoxicology, 2010, 32(4): 607-610.

DOI：10.3109/08923971003631417

• Antiplasmodial activity
• Chinese Hawthorn
• cytotoxicity
• Plasmodium falciparum
• procyanidins

The methanolic extract of the leaves of Chinese Hawthorn was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the method of parasite lactate dehydrogenase assay. Four oligomeric procyanidins, such as epicatechin-(4 beta -> 8)-epicatechin-(4 beta -> 8)-epicatechin (1), epicatechin-(4 beta -> 8)-epicatechin-(4 beta -> 6)-epicatechin (2), epicatechin-(4 beta -> 6)-epicatechin-(4 beta -> 8)-epicatechin (3), and epicatechin-(4 beta -> 8)-epicatechin-(4 beta -> 8)-epicatechin-(4 beta -> 8)-epicatechin-(4 beta -> 8) (4), were isolated and evaluated for in vitro antiplasmodial activity, as well as for their cytotoxic potential on SK-OV-3 cancer cell lines. Three procyanidins showed notable growth inhibitory activity against chloroquine-sensitive strains of P. falciparum with IC(50) values of 2.7 mu M (SI values of > 55.5). The compounds showed no significant cytotoxicity (IC(50) > 150 mu M) toward the SK-OV-3 cancer cell line. This is the first report on the antiplasmodial activity of these oligomeric procyanidins from Chinese Hawthorn.</.

• 出版日期2010-12