Association of Matrix Metalloproteinase-9 and p53 Gene Polymorphisms with Genetic Susceptibility to No-small-cell Lung Cancer

作者：Zhao Ying hao; Ma Tong hui; Zheng Yong chen; Zhang Kun; Yang Jing bo; Yang Long fei; Yang Zhi guang; Shao Guo guang^*

来源：Chemical Research in Chinese Universities, 2011, 27(1): 80-82.

• Single nucleotide polymorphisms(SNPs)
• No-small-cell lung cancer(NSCLC)
• Matrix metalloproteinase-9(MMP-9)
• p53
• Susceptibility

Matrix metalloproteinase-9(MMP-9) and p53 genes play an essential role in the multi-step process of tumorigenesis in lung cancer. Single nucleotide polymorphisms(SNPs) of MMP-9 and p53 genes are associated with the risk and progression of many cancers. In this study, we evaluated the association of the R279Q polymorphism of MMP-9 of the A(1)/A(2) polymorphism of p53 gene with the risk of no-small-cell lung cancer(NSCLC) in Han population of Northeast China. We examined the frequency of SNPs in the two kinds of genes of 50 patients with NSCLC and 50 cancer-free controls frequency-matched by age and sex. Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique was used to determine the genotypes. The results indicate that the 279RR genotype in MMP-9 gene and the A(1)/A(2) genotype in p53 gene show a significantly increased risk of NSCLC. Therefore, the MMP-9 279RR and p53 A(1)/A(2) genotypes may be used as markers for susceptibility to NSCLC in Han population of Northeast China.

• 出版日期2011-1-25
• 单位吉林大学