New heterocyclic chalcones. Part 6. Synthesis and cytotoxic activities of 5-or 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones

作者：Ivanova Yordanka B; Momekov Georgi T; Petrov Ognyan I^*

来源：Heterocyclic Communications, 2013, 19(1): 23-28.

DOI：10.1515/hc-2012-0081

• apoptosis
• 2(3H)-benzoxazolone
• chalcone
• cytotoxicity
• MTT

A number of chalcones bearing an oxazole cycle were synthesized by Claisen-Schmidt condensation of 5-acetyl-2(3H)-benzoxazolone or 6-acetyl-2(3H)-benzoxazolone and the appropriate aldehydes. The chalcones were evaluated for cytotoxic activity against several tumor cell lines - BV-173 (human B cell precursor leukemia), MCF-7 and MDA-MB-231 (human breast adenocarcinoma) using the MTT-dye reduction assay. The tested compounds exhibit concentration-dependent cytotoxic effects at micromolar concentrations. Exposure of the BV-173 tumor cell line to compound 3f results in strong mono- and oligonucleosomal fragmentation of genomic DNA, as evidenced by a %26apos;cell death detection%26apos; ELISA kit, which unambiguously indicates that the induction of apoptosis is implicated in the cytotoxic mode of action of the tested compound.

• 出版日期2013-3