Assessment of arsenic in colostrum and cord serum and risk exposure to neonates from an island population in China

作者：Xu, Chenye; Tang, Mengling; Zhu, Siyu; Naranmandura, Hua; Liu, Weiping^*

来源：Environmental Science and Pollution Research, 2016, 23(22): 22467-22476.

DOI：10.1007/s11356-016-7265-1

• Arsenic
• Colostrum
• Umbilical cord serum
• Correlation analysis
• Exposure assessment
• Inorganic arsenic speciation

Arsenic (As) has been proven to be highly toxic to humans, but limited attention has focused on exposure levels and potential risks to mother-neonate pairs of coastal populations. This study was conducted by examining the As concentration in colostrum and umbilical cord serum collected from 106 mother-neonate pairs living on Shengsi Island, facing the Yangtze River estuary and Hangzhou Bay in China. Average concentrations of total As in colostrum and cord serum were 18.51 +/- A 7.00 and 19.83 +/- A 10.50 mu g L-1. One-way ANOVA analysis showed delivered ages and source of drinking water played significant roles in influencing the maternal exposure patterns. Correlation analysis indicated a significantly positive association between As concentrations in colostrum and cord serum. Multivariable linear regression models adjusted for other confounders clarified the dose-response relationship with a coefficient value of 0.23 and a 95 % confidence interval of (0.006, 0.492); p < 0.05. The calculated daily intake of total As for neonates through breastfeeding was in the range from 0.413 to 3.65 mu g kg(-1) body weight, and colostrum As, especially the most toxic species, inorganic arsenic (iAs), would pose a risk to neonates.

• 出版日期2016-11
• 单位浙江大学