A Bayesian SIRS model for the analysis of respiratory syncytial virus in the region of Valencia, Spain

作者：Corberan Vallet Ana; Santonja Francisco J^*

来源：Biometrical Journal, 2014, 56(5): 808-818.

DOI：10.1002/bimj.201300194

• Discrete epidemic model
• Epidemic prediction
• Infectious diseases
• Respiratory syncytial virus
• SIRS model

We present a Bayesian stochastic susceptible-infected-recovered-susceptible (SIRS) model in discrete time to understand respiratory syncytial virus dynamics in the region of Valencia, Spain. A SIRS model based on ordinary differential equations has also been proposed to describe RSV dynamics in the region of Valencia. However, this continuous-time deterministic model is not suitable when the initial number of infected individuals is small. Stochastic epidemic models based on a probability of disease transmission provide a more natural description of the spread of infectious diseases. In addition, by allowing the transmission rate to vary stochastically over time, the proposed model provides an improved description of RSV dynamics. The Bayesian analysis of the model allows us to calculate both the posterior distribution of the model parameters and the posterior predictive distribution, which facilitates the computation of point forecasts and prediction intervals for future observations.

• 出版日期2014-9