科研之友
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摘要
The release of insulin by pancreatic beta-cells involves a complex interplay of conductances that generate oscillations and drive secretion. A recent report identifies a new player in this process, the ion channel TRPM5. TRPM5 was originally identified in taste cells, where it forms a Ca2+-activated cation channel that is required for sensory responses to bitter and sweet tastes. New research now shows that TRPM5 is expressed within the pancreatic islets of Langerhans, where it regulates the frequency of Ca2+ oscillations and contributes to insulin release by beta-cells.
- 出版日期2010-10
