Application of a 3(3) Box-Behnken Design to Optimize the Extraction of Eleven Fluoroquinolones from Poultry Muscle and Kidney Using a QuEChERS Approach via Liquid Chromatography Tandem Mass Spectrometry: the Easy Use of Microsoft Excel (R) in Multivariate Analysis

Rocha Diego G; Santos Flavio A; Augusti Rodinei; Faria Adriana F<sup>*</sup>

doi:10.5935/0103-5053.20150264

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Application of a 3(3) Box-Behnken Design to Optimize the Extraction of Eleven Fluoroquinolones from Poultry Muscle and Kidney Using a QuEChERS Approach via Liquid Chromatography Tandem Mass Spectrometry: the Easy Use of Microsoft Excel (R) in Multivariate Analysis

作者：Rocha Diego G; Santos Flavio A; Augusti Rodinei; Faria Adriana F^*

来源：Journal of the Brazilian Chemical Society, 2016, 27(1): 221-226.

DOI：10.5935/0103-5053.20150264

摘要

This work presents an optimization of a quick, easy, cheap, effective, rugged and safe (QuEChERS) extraction approach of eleven fluoroquinolones in poultry muscle and kidney using a 3(3) Box-Behnken factorial design. All the data treatment was performed using Microsoft Excel (R) 2010. The suitability of the developed method was confirmed by two proficiency tests for ciprofloxacin and enrofloxacin.