Absence of tissue ingrowth through the textile fabric in a series of explanted clinic stent-grafts

作者：Wei, Dangheng; Guidoin, Robert^*; Marinov, Georgi; Yin, Tieying; Zhang, Ze; Douville, Yvan; Koebke, Jürgen; How, Thien; Nutley, Mark; Knifka, Jutta; Lin, Jing; Li, Bin; Samis, Gregory; Wang, Lu; Dionne, Guy; Gilbert, Nathalie

来源：Journal of Long-Term Effects of Medical Implants, 2013, 23(4): 339-357.

DOI：10.1615/JLongTermEffMedImplants.2013006657

• Adverse incident
• Aortic aneurysms
• Endovascular surgery
• Fabric structures
• Preliminary assessment
• Stent grafts
• Talent stent grafts
• Tissue plasminogen activator (tPA)

Using the retrieved devices from one autopsy and five reoperations, the biocompatibility of explanted Talent stent-grafts was investigated to highlight the capacity of the fabric to act as an effective scaffold to regenerate a blood conduit. The autopsy device was encapsulated both internally and externally, but the capsules did not penetrate through the fabric structure. The reoperation devices showed discrete patches of compact fibrin and irregularly scattered mural thrombi. Positive staining of α-actin, tissue plasminogen activator (tPA), urokinase (uPA), urokinase receptor (uPAR), and urokinase inhibitors (PAI 1, PAI 2, PAI 3, and protease nexin), and D-dimer was more frequently identified in the autopsy sample than in the reoperation samples. This preliminary assessment shows that the stent-graft retrieved during autopsy was better healed than those explanted at reoperation.

• 出版日期2013
• 单位University of LIVERPOOL; Laval University; 中国人民解放军第二军医大学; The University of Calgary; The University of Liverpool; 东华大学; University of calgary