科研之友
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摘要
Streptococcus pneumoniae infections which are relatively unusual in the neonates, are associated with substantial morbidity and mortality. Although S.pneumoniae has more than 90 serotypes, invasive disease is more common with certain serotypes. Pneumococcal polysaccharide and conjugate vaccines are developed against the serotypes that cause invasive disease. Until now invasive pneumococcal diseases have been defined due to various serotypes in the neonatal period. Here we present a neonate with an invasive pneumococcal disease due to S.pneumoniae serotype 7F which has not yet been reported in the literature. A 3180 g infant was born to a healthy 31 year old primigravida by normal vaginal delivery at 39 weeks gestation. Since the infant developed uneasiness, decreased sucking reflex and respiratory difficulty at postnatal 10th hour, he was admitted to the neonatal intensive care unit. Upon admission to intensive care unit mechanical ventilation, fluid replacement and empirical penicillin G and netilmycin had been initiated since the patient had hypotension, hypothermia and tachycardia. The infant later developed severe metabolic acidosis and had anemia, leukocytosis and high CRP values. CSF culture revealed no bacterial growth, however, S.pneumoniae was grown in the blood culture. The isolate was identified as serotype 7F by capsule swelling reaction. The vaginal specimen taken from the mother for the determination of the infectious foci revealed no pathogen growth. The patient%26apos;s general condition improved after the second day of supportive treatment and antibiotherapy. Since the isolate was penicillin susceptible, the treatment continued with penicillin G and netilmycin for 14 days and the case was discharged with cure. This case was presented to emphasize that S.pneumoniae serotype 7F might lead to invasive disease not only during childhood but also during early neonatal period.
- 出版日期2013-1
