Near Full-Length Sequence Analysis of HIV Type 1 BF Recombinants from Italy

作者：Saladini Francesco^*; Foley Brian T; Rosi Andrea; Vicenti Ilaria; Nannetti Giulio; Meini Genny; Razzolini Francesca; Zazzi Maurizio

来源：AIDS Research and Human Retroviruses, 2012, 28(3): 299-303.

DOI：10.1089/aid.2011.0002

Recombination between HIV-1 subtypes B and F has generated several circulating and unique recombinant forms, particularly in Latin American areas. In Italy, subtype B is highly prevalent while subtype F is the most common pure non-B subtype. To investigate the recombination pattern in Italian BF recombinant viruses, we characterized full-length sequences derived from 15 adult patients, mostly Italian and infected by the heterosexual route. One of the BF mosaics was a CRF29, three sequences clustered with low bootstrap values with CRF39, CRF40, and CRF42. With the exception of the CRF29-like sequence, the other recombination patterns were unique, but two possible clusters were identified. Analysis of the gp120 V3 domain suggested a possible link with subtype F from Eastern Europe rather than from Latin America, favoring the hypothesis of local recombination between clade B and F viruses over that of import of BF recombinants from Latin America. HIV-1 subtypes B and F appear prone to generation of unique recombinants in Italy, warranting epidemiological surveillance and investigation of a possible clinical significance.

• 出版日期2012-3