A novel method for examining corneal endothelial cell morphology in infants

作者：Rufai Sohaib R; Tan Nicole Y; Barbara Ramez; Hartrey Rachael; Self Jay E^*

来源：Journal of AAPOS, 2017, 21(3): 241-243.

DOI：10.1016/j.jaapos.2017.01.002

Previous studies have suggested that central corneal endothelial cell density (ECD) decreases from 6,100 cells/mm(2) in neonates to 3,100 cells/mm(2) in 10-year-olds. Currently data on ECD in young children as well as the trend for ECD decrease during childhood is sparse because of the difficulty of examination using existing clinic-based specular microscopes. We developed a novel method of imaging young children intraoperatively with the goal of beginning to establish age-specific normative data for ECD and hexagonality of cells (%HEX). Children were imaged using our novel technique under general anesthesia or awake in clinic using a child-friendly technique. A total of 58 children were recruited (mean age, 5.50; range, 0.44-10.36). Our cohort displayed a significant linear decrease in ECD with age (r = -0.56, P < 0.001). No correlation was found between %HEX and age (r = -0.10, P = 0.48).

• 出版日期2017-6